Predicting CYP3A-mediated midazolam metabolism in critically ill neonates, infants, children and adults with inflammation and organ failure.

In the healthy adult population, clearance was well predicted, assuming normal CRP levels and the lack of organ failure that would be expected (Figure 3 ); however, the drug distribution was misspecified, resulting in a clear trend in the CWRES vs . time plot (Figure 2 J).

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