TUBB3 expression correlates with advanced tumor stages For all 280 patients with IHC and mRNA data we observed a higher expression of TUBB3 in more advanced tumors (Table 1 ) Also for patients without neoadjuvant therapy we found a significant trend for more TUBB3 expression in advanced pT-categories (pT3/4) compared to pT1/2 (p-trend=0.0001) and in patients with pN+ compared to patients without lymph node metastasis (p-trend=0.023).
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High protein and mRNA expression levels of TUBB3 (class III ß-tubulin) are associated with aggressive tumor features in esophageal adenocarcinomas.
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