Pharmacogenetic stimulation of neuronal activity increases myelination in an axon-specific manner.

There was also a strong trend toward an increase in the overall density of ASPA + cells (Fig. 3e , P = 0.054, n = 4 mice, Welch’s corrected t -test) and a statistically significant 76.1 ± 21.8% increase in the density of newly differentiated EdU + /ASPA + oligodendrocytes in response to neuronal activity stimulation at this later age (Fig. 3b, f , P = 0.017, n = 4 mice, Welch’s corrected t -test).

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6e ), however, in adult mice there was a slight trend for higher apoptosis in newly generated oligodendrocytes in hM3Dq/GFP mice compared to controls ( P = 0.07, n = 4 mice, Welch’s corrected t -test; Supplementary Fig. 6f-h ).

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