Elevated EBNA-1 IgG in MS is associated with genetic MS risk variants.

Neurol Neuroimmunol Neuroinflamm · 2017 · PMC5778394 · PMID 29379819

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closest p · 1.6× alpha

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showed a trendp = 0.08so close (0.05 < p ≤ 0.1)

Previous associations of HLA-DRB1*1501 with elevated EBNA-1 IgG titers 12 showed a trend for significance (OR 1.43, 95% CI 0.96–2.13; p = 0.08) using a multivariate logistic regression model ( figure 3A ).

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a trend toward significanceno p-value reported

Increased EBNA-1 IgG levels were significantly associated with risk alleles of SNP rs2744148 (SOX8), rs11154801 (MYB), rs1843938 (CARD11), and rs7200786 (CLEC16A/CIITA) in an interaction model and a trend toward significance for rs3135388 (HLA-DRB1*1501).

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