Adipose tissue ATGL modifies the cardiac lipidome in pressure-overload-induced left ventricular failure.

In atATGL-KO mice we observed a moderate induction of collagen fibers ( Fig 1L–1N ) and fibrotic marker genes ( Fig 1O and 1P ) by TAC, however, this did not reach statistical significance ( Fig 1N ) suggesting attenuated pressure-induced fibrotic remodeling in the absence of atATGL.

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