Kinin B1 receptor as a novel, prognostic progression biomarker for carotid atherosclerotic plaques.

Spearman correlation test showed that there was a close and highly significant relationship between serum level of B1R with histological staining of B1R in stroke patients (r=0.54, P<0.001) ( Fig. 4A ), TIA (r=0.81, P<0.001) and asymptomatic patients (r=0.61, P<0.001), suggesting of a notable correlation between changes in serum B1R level and changes in plaques in the progression of atherosclerotic plaques.

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In this study, plaques from stroke patients showed a significant reduction of macrophage content and a clear trend of increasing numbers of smooth muscle cells from <30 to >180 days.

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