IL-1β mediates lung neutrophilia and IL-33 expression in a mouse model of viral-induced asthma exacerbation.

Results IL-1β −/− mice exhibited reduced lung inflammation compared to WT mice at dsRNA-induced exacerbation Total protein concentration in BALF, likely reflecting plasma exudation [ 17 ], was increased at exacerbation in WT mice ( p < 0.01) compared to WT control (HDM/Saline) group while the IL-1β −/− mice showed a trend towards lower levels of total proteins at exacerbations compared to WT mice (Fig. 2a ).

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With the present size of test groups, the reduced chemotactic factors in KO animals were associated with effects on the neutrophilia of exacerbations that only bordered on significance.

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