Low-dose omega-3 fatty acids in margarines prove disappointing as secondary prevention.

This trial, which was carried out in collaboration with 32 hospitals in the Netherlands, did show a reduction in the rate of cardiovascular events, approaching significance in the sub-group of women receiving ALA supplements (p = 0.07).

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However, there were borderline significant reductions among post-MI sub-groups, including diabetic patients and women receiving alpha-linolenic acid (ALA) supplements, said principal investigator Daan Kromhout from Wageningen University, the Netherlands, in a hot-line session at the ESC.

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