MAP2 protein expression was significantly reduced ( F (3,18) = 7.792, p = 0.0015, ANOVA, ** post hoc pLSD p ≤ 0.001) with age and rescued by LT treatment (pLSD p ≤ 0.01) and possibly ST treatments (borderline significant, pLSD p = 0.06), consistent with the view that the cytoskeletal genomic alterations are reflected in overall function and protein structure of the cytoskeleton.
The path length to platform results were highly similar to latency, although the differences between the FKBP1b groups and the ACs were only of borderline significance (vs ACs: LT, p = 0.078; ST, p = 0.08, YCs, p = 0.006, pLSD).
AC animals again exhibited highly significant deficits in path length and latency compared with YCs, but both ST and LT groups exhibited path length and latency scores that were highly similar to those of YCs and significantly reduced compared with AC animals (latency; AC vs: LT, p < 0.0001, ST, p < 0.0001; YC, p < 0.0001; path length, AC vs: LT, p = 0.0001, ST, p = 0.0001; YC, p = 0.0008, pLSD; Fig. 2 B ).
Although there was a strong trend for young animals to outperform ACs during training, no significant effects of treatment were seen in latency and path length measures over this 4 d training phase, similar to results in Gant et al.