35 – 37 This primary efficacy endpoint did not reach statistical significance in the flexible dose study in patients receiving BRV 50–150 mg/day, 38 nor for lower doses of 5 mg and 20 mg/day. 35 , 37 , 39 Statistically significant seizure freedom rates of 4.0–5.2% were achieved in patients treated with 100–200 mg BRV daily in the largest study. 40 Health-related quality of l
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