randomized mRCC patients progressing after a previous VEGFR-targeted treatment to either lenvatinib monotherapy, everolimus monotherapy, or their combination at reduced doses; overall, lenvatinib plus everolimus and lenvatinib alone resulted in a significant PFS benefit, as compared to everolimus monotherapy; PFS in the combination group was almost double in comparison to the lenvatinib alone group, although this difference did not reach statistical significance.
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