ABCC6 plays a significant role in the transport of nilotinib and dasatinib, and contributes to TKI resistance in vitro, in both cell lines and primary patient mononuclear cells.

PLoS One · 2018 · PMC5792028 · PMID 29385210

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failed to reach statistical significanceno p-value reported

While superior rates of MMR were observed in both newly diagnosed patients as well as imatinib-resistant or–intolerant patients receiving PPI co-treatment, the differences failed to reach statistical significance.

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