Derepression of the Iroquois Homeodomain Transcription Factor Gene IRX3 Confers Differentiation Block in Acute Leukemia.

There was highly significant negative enrichment of IRX3-repressed genes in human IRX3 high versus IRX3 low human AMLs whether all AMLs were considered or just those expressing high levels of HOXA9 ( Figure 5 D).

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There were also significantly fewer Mac1 + Gr1 − leukemia cells in Hoxa9 / IRX3 recipients and, on average, double the percentage of cells positive for the stem and progenitor marker KIT ( Figure 3 J), although in view of heterogeneous levels of expression, this difference did not reach statistical significance.

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