KIBRA is associated with accelerated cognitive decline and hippocampal atrophy in APOE ε4-positive cognitively normal adults with high Aβ-amyloid burden.

Further, relative to APOE ε4 + ve/ KIBRA T carriers, the APOE ε4 + ve/ KIBRA non-T carrier group showed a nominally significantly greater rate of decline on the verbal episodic memory composite, however after FDR correction this remained only a strong trend (p = 0.018, q = 0.055) over six years (Fig. 2 , Table 3 ).

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