Mfn2 ablation causes an oxidative stress response and eventual neuronal death in the hippocampus and cortex.

Neuronal number in the hippocampus CA1 and CA2 regions quantified using the sections stained for NeuN revealed that the number of pyramidal neurons in the CA2 region remained constant with age (not shown), yet the number of pyramidal neurons in the CA1 region showed a trend towards decrease at 12 weeks of age which became significant at age 18 weeks (Fig. 5 e).

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