Prevalence of infant sneezing without colds and prediction of childhood allergy diseases in a prospective cohort study.

Other limitations of this study include the following: 1) the relative high retention rates at newborn, 18 months and 3 years of age (> 75%) but lower retention rate at 6 years of age may have affected the power of the prediction of allergic diseases in children at 6 years of age; 2) Although infant cough without colds (no symptom, occasional or frequent) in the Chi-square for trend analysis revealed a significant trend on prediction of AS, the sizes of populations in AD, AR or AS for the group ≥ 3 days per week were less than 13 (between 7 and 13), suggesting the statistical power is not qualified for the inference; 3) using questionnaires to collect allergic symptoms by parents may have a recall bias, although we made a group consensus to collect the data by differentiating common colds with a course of 5 to 7 days of continual daily symptoms from infant sneezing or cough without colds at morning and/or night occurrence more than 2 weeks in the last 6 months.

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