Systems biology of the IMIDIA biobank from organ donors and pancreatectomised patients defines a novel transcriptomic signature of islets from individuals with type 2 diabetes.

Diabetologia · 2018 · PMC5803296 · PMID 29185012

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Among the 19 genes dysregulated in type 2 diabetic islets, ARG2 and PPP1R1A were also differentially expressed in non-diabetic OD islets exposed ex vivo to high glucose (22.2 mmol/l) for 48 h, while CHL1 , FBX032 and SLC2A2 showed a trend towards dysregulation (ESM Table 9 ).

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