Long-term health-related quality-of-life and symptom response profiles with arformoterol in COPD: results from a 52-week trial.

Similarly, on the SGRQ domains, significantly larger improvements were observed for the arformoterol-versus placebo-treated patients in the Symptoms score (6.34 vs 4.25 points; LSM difference vs placebo: −2.09 [95% CI: −3.99 to −0.19], P =0.031) and Impacts score (3.91 vs 0.97 points; LSM difference vs placebo: −2.94 [95% CI: −4.70 to −1.17], P =0.001), but the Activity score differences did not reach statistical significance (3.57 vs 1.75 points; LSM difference vs placebo: −1.822 [95% CI: −3.70 to −0.06], P =0.057; Figure 1B–D , respectively).

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