Lentivirus-mediated expression of human secreted amyloid precursor protein-alpha prevents development of memory and plasticity deficits in a mouse model of Alzheimer's disease.

There was also a significant main effect of treatment group on proximity to the platform with Tukey post-hoc tests revealing a strong trend for an impairment in the Tg-control group relative to the WT-control group, and a significant enhancement of performance back to WT levels for the Tg-sAPPα group, compared to the Tg-control group (Fig. 2c, d ).

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