Intragenic DNA methylation of PITX1 and the adjacent long non-coding RNA C5orf66-AS1 are prognostic biomarkers in patients with head and neck squamous cell carcinomas.

PLoS One · 2018 · PMC5806891 · PMID 29425237

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a trend towards significanceno p-value reported

A trend towards significance in survival was seen in oral cavity and oropharynx tumors.

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showed a trendno p-value reported

Kaplan-Meier curves showed a trend towards better survival in patients with high PITX1 mRNA levels and hypomethylated PITX1 exon 3 gene locus, but this result failed to be statistically significant (p = 0.21 and p = 0.12, respectively).

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failed to reach significanceno p-value reported

When correlating lincRNA C5orf66-AS1 hypo- and hypermethylation with p16 expression, a trend towards significance was seen in survival (p16-positive: n = 41, p = 0.086; p16-negative: n = 74, p = 0.12, Fig 5 ), which was supported by Kaplan-Meier curves, but ultimately failed to reach significance.

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