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Mitochondrial deficits and abnormal mitochondrial retrograde axonal transport play a role in the pathogenesis of mutant Hsp27-induced Charcot Marie Tooth Disease.

Hum Mol Genet · 2017 · PMC5808738 · PMID 28595321

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Similarly, there was an increase in the number of cells positive for superoxide in Pro39Leu and Arg140Gly expressing cells, although this increase did not reach statistical significance (76.0 ± 7.9% in Pro39Leu and 70.1 ± 9.0% in Arg140Gly mutants; Fig. 6Bii ).

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