Measuring the impact of medicines regulatory interventions - Systematic review and methodological considerations.

Figure 3 shows how study designs and analytical methods evolved over time with a significant trend of increasing use of ITS regression analysis ( P = 0.003).

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Measuring the impact of pharmacovigilance interventions is challenging as treatment and disease outcomes often overlap, and there may be significant time lags until clinical effects are seen with many existing studies being ecological in nature.

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