The p55TNFR-IKK2-Ripk3 axis orchestrates arthritis by regulating death and inflammatory pathways in synovial fibroblasts.

Nat Commun · 2018 · PMC5809454 · PMID 29434332

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did not reach statistical significanceno p-value reported

Interestingly, naive Ikk2 -null cells exposed to TNF presented slightly upregulated the Il1b RNA expression; however, the difference did not reach statistical significance compared to TNF-exposed IKK2-expressing SFs (Fig. 4d ).

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