Barely Significant
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Metastatic uveal melanoma showing durable response to anti-CTLA-4 and anti-PD-1 combination therapy after experiencing progression on anti-PD-1 therapy alone.

J Immunother Cancer · 2018 · PMC5809910 · PMID 29433557

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a significant trendno p-value reported
They reported a significant trend for improved outcomes in patients with extrahepatic disease contrary to our patient who had hepatic disease progression [ 31 ].

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.