The impact of EGFR mutations on the incidence and survival of stages I to III NSCLC patients with subsequent brain metastasis.

The cumulative incidence of BM seemed higher in patients harboring EGFR mutations than those without EGFR mutations although it did not reach statistical significance (hazard ratio [HR] = 1.75, 95% confidence interval [CI] = 0.73~1.81).

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We also found EGFR mutations were more common among elderly patients, and that such patients tended to have worse survival after diagnosis of BM compared to younger patients, with borderline significance (HR = 1.036).

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