Inhibition of the NEDD8 conjugation pathway induces calcium-dependent compensatory activation of the pro-survival MEK/ERK pathway in acute lymphoblastic leukemia.

Oncotarget · 2018 · PMC5814156 · PMID 29464016

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showed a trendp < 0.05actually significant

Kaplan-Meier analysis also showed a trend of improved survival in mice treated with pevonedistat alone and in combination over the control group (p < 0.05) (Figure 6C ).

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