Aggregometry studies showed that pigs treated with SynthoPlate had a stable platelet aggregation profile while pigs treated with unmodified (control) particle demonstrated a trend for decreasing platelet aggregation and pigs treated with saline showed a trend for platelet hyper-aggregation (Supplemental Figure S.8.A).
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Intravenous synthetic platelet (SynthoPlate) nanoconstructs reduce bleeding and improve 'golden hour' survival in a porcine model of traumatic arterial hemorrhage.
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