Loss of Protein Kinase Novel 1 (PKN1) is associated with mild systolic and diastolic contractile dysfunction, increased phospholamban Thr17 phosphorylation, and exacerbated ischaemia-reperfusion injury.

However, posterior wall thickness at diastole (PWTD) was significantly higher in KO hearts ( Figure 10 A ). Furthermore, PKN1 KO hearts had a trend towards altered functional characteristics compared to wild type hearts under conditions of decreased preload (IVC occlusion), including decreased end systolic pressure-volume relationship (ESPVR), increased end diastolic pressure-volume relationship (EDPVR) and decreased preload recruitable stroke work (PRSW), although these changes did not reach statistical significance (see Supplementary material online, Figure S8 ).

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