When using all the 3 FETUB SNPs (rs3733159, rs4686434, and rs6785067) as instrument variables simultaneously, per SD greater genetically predicted fetuin-B concentration was slightly associated with lower HOMA-IR (−0.09 [95%CI, −0.62–0.44] 10 −6 mol IU L −2 , P = .738), but it did not reach statistical significance.
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Common genetic variants in the FETUB locus, genetically predicted fetuin-B levels, and risk of insulin resistance in obese Chinese adults.
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