EDC IMPACT: Molecular effects of developmental FM 550 exposure in Wistar rat placenta and fetal forebrain.

Endocr Connect · 2018 · PMC5817967 · PMID 29351906

Europe PMC DOI

hedged sentences

0.0700

closest p · 1.4× alpha

0.0700

boldest claim

The sentences

did not reach statistical significanceP = 0.07so close (0.05 < p ≤ 0.1)

A similar trend was found for Pparg; however, it did not reach statistical significance ( U = 53, P = 0.07) and the directionality did not reflect the change in expression observed in the RNA-seq data.

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not quite statistically significantP = 0.07so close (0.05 < p ≤ 0.1)

Stratification by sex revealed that, although not quite statistically significant, female-associated placentas from the high-dose group appeared to have elevated levels of 5-HT compared to controls ( U = 3, P = 0.07; Fig. 4B ). 5-HIAA, 5-HTs primary metabolite, was found to be significantly reduced in placentas from the low-dose group compared to controls ( U = 17, P ≤ 0.02; Fig. 4C ).

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