66 In addition, each of these genes was also nominally significant in a GWAS of neuroticism, with DRD2 being genome-wide significant in both phenotypes. 49 A comparison with a UK Biobank GWAS of self-rated health 22 showed that four of the five genes ( DRD2 , PRRC2C , C3orf84 and ASXL3 ) were significant across phenotypes.
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