Tph2-/- female mice restore socio-sexual recognition through upregulating ERα and OTR genes in the amygdala.

Moreover, there was a clear trend that the protein expression of ERα in the amygdala of reproduction-experienced Tph2 −/− females was higher than in sexually naive Tph2 −/− females (0.6374 ± 0.2385 vs. 1.4734 ± 0.4743, independent-samples t -test, t = 1.575, df = 8, P = 0.154, Fig 3d ), although the difference did not reach statistical difference.

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They also exhibited a tendency to prefer the urine of genetically dissimilar Balb/c males to that from genetically similar C57BL/6 males (Wilcoxon rank sum test, Z = 1.726, N = 12, P = 0.084, marginal significance, Fig 2b ).

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