The small molecule ISRIB rescues the stability and activity of Vanishing White Matter Disease eIF2B mutant complexes.

Elife · 2018 · PMC5829914 · PMID 29489452

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did not reach statistical significanceno p-value reported

The γI346T mutation caused a 20% reduction (that did not reach statistical significance) in γ subunit in one clone, and a significant 90% reduction in the second clone.

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