<i>In vitro</i> and <i>in vivo</i> evidence for uncoupling of B-cell receptor internalization and signaling in chronic lymphocytic leukemia.

In keeping with post-activation anergy, in the majority of patients (14/21) there was more efficient uptake of pHrodo-αIgM in the CXCR4 dim CD5 bright subset, however, there was significant variability and, in the whole population, this did not reach statistical significance ( Figure 3B ; n=21; P =0.281).

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