Pathological Endogenous α-Synuclein Accumulation in Oligodendrocyte Precursor Cells Potentially Induces Inclusions in Multiple System Atrophy.

Stem Cell Reports · 2018 · PMC5830961 · PMID 29337114

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did not reach statistical significanceno p-value reported

Conversely, the protein expression levels of p62 and LC3-II in OLGs treated with α-syn PFFs only slightly increased, which did not reach statistical significance.

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a decreasing trendno p-value reported

The decrease of these OLG-specific markers was accompanied with an increase in the protein expression levels of PDGFRα and a decreasing trend of Mbp mRNA expression levels, suggesting insufficient differentiation as a result of α-syn PFF application ( Figures S4 F–S4I).

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