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Medication changes after switching from CONCERTA® brand methylphenidate HCl to a generic long-acting formulation: A retrospective database study.

PLoS One · 2018 · PMC5831385 · PMID 29489906

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the AG formulation of long-acting MPH was in the expected direction but did not reach statistical significance versus a null hypothesis of no difference, and there is concern about potential residual bias.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.