Development of tissue inflammation accompanied by NLRP3 inflammasome activation in rabbits infected with Treponema pallidum strain Nichols.

BMC Infect Dis · 2018 · PMC5831842 · PMID 29490620

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showed a trendno p-value reported

NLRP3 inflammasome activation in the cutaneous lesions of infected rabbits In the infected rabbit group, the NLRP3 mRNA levels showed a trend in elevation to decline and reached a peak at 18 d post-infection in the BPG treatment subgroup and at 21 d in the no BPG treatment subgroup.

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a decreasing trendno p-value reported

Similar to the trend in NLRP3 , caspase-1 mRNA showed an initial increase and then a decreasing trend later in four organs (kidney, liver, lung, and testis).

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.