An algorithmic approach for the treatment of severe uncontrolled asthma.

In a proof-of-concept study, including patients on GINA Step 4 treatment with severe persistent asthma, tiotropium add-on treatment provided highly significant improvements in peak forced expiratory volume in 1 s (FEV 1 ) [ 34 ].

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In the first phase 3 study published in 2011, in a cohort of 106 patients with eosinophilic asthma (sputum eosinophils ≥3%), reslizumab significantly reduced sputum eosinophils, improved lung function and showed a trend toward better asthma control [ 54 ].

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