Synthetic 3',4'-Dihydroxyflavone Exerts Anti-Neuroinflammatory Effects in BV2 Microglia and a Mouse Model.

Western blot analysis indicated that LPS injection elevated i NOS and COX-2 expression levels in the mouse brains, but 3′,4′-dihydroxyflavone effectively lowered these expression levels, with the exception of COX-2, for which the difference did not reach statistical significance ( Fig. 5C, 5D ).

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