Serum anti-flagellin and anti-lipopolysaccharide immunoglobulins as predictors of linear growth faltering in Pakistani infants at risk for environmental enteric dysfunction.

Notable findings included: (1) while we observed a clear trend of increasing anti-LPS and anti-flic IgA and IgG concentrations over the first year of life, anti-flic and anti-LPS IgA were both lower than in our Boston controls; (2) anti-LPS IgA correlated significantly with serum CRP, AGP and Reg1 at 6 months and with fecal MPO at 9 months; (3) high anti-LPS IgA levels at 6 months of age and higher anti-flic IgA levels at 9 months of age were associated with a trend to greater decrease in LAZ scores over 18 months; (4) Compared to children in first quartile of anti-LPS IgA level, those in the second and third quartile had an increased risk of stunting.

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