nominally significantP < 0.02
Given that several atherosclerosis risk factors have been associated with AS 6 , 18 , 19 , we tested the novel AS variants for association with the traditional cardiovascular risk factors and observed a nominally significant association ( P < 0.02) between rs1830321 and systolic and diastolic blood pressure in Iceland (Supplementary Data 3 ) and in data from the UK Biobank ( https://biobankengine.stanford.edu/search# ).