Safety, tolerability and efficacy of intra-articular Progenza in knee osteoarthritis: a randomized double-blind placebo-controlled single ascending dose study.

J Transl Med · 2018 · PMC5840781 · PMID 29510712

Europe PMC DOI

hedged sentences

0.0050

closest p · 0.1× alpha

0.5260

boldest claim

The sentences

highly significantp ≤ 0.005actually significant

There was a statistically significant within group improvement in VAS pain scores from baseline at all timepoints for the PRG combined group, with highly significant improvements seen at months 3, 6, 9 and 12 (p ≤ 0.005) while VAS pain scores in the placebo group showed marginal improvement.

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did not reach statistical significancep = 0.526not close (p > 0.1)

Overall change in the placebo group was marginal and did not reach statistical significance (− 0.73, 95% CI − 3.14, 1.67, p = 0.526).

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.