Generation of iPSCs carrying a common LRRK2 risk allele for in vitro modeling of idiopathic Parkinson's disease.

In contrast, neurons from iPD samples treated with CZC showed a reduction of aSYN, which almost reached statistical significance (p = 0.0523) ( Fig 7D ).

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Although our results did not reach statistical significance due to the reduced sample size, and the detected phenotypes were very subtle as expected in the context of an idiopathic pathology, we posit that our study represents a useful contribution to the PD community, since it highlights the potentials and approachable limitations of our disease modeling tools.

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