Comparison of neuroprotective efficacy of poly-arginine R18 and R18D (D-enantiomer) peptides following permanent middle cerebral artery occlusion in the Wistar rat and in vitro toxicity studies.

PLoS One · 2018 · PMC5841795 · PMID 29513757

Europe PMC DOI

hedged sentences

0.0580

closest p · 1.2× alpha

0.0580

boldest claim

The sentences

showed a trendp = 0.058so close (0.05 < p ≤ 0.1)

Functional outcomes and weight loss measurements When compared to the vehicle, the R18D treatment group showed a significantly improved neurological score ( p = 0.02), while the R18 treatment group showed a trend to improvement in neurological score ( p = 0.058; Fig 2A ).

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highly significantno p-value reported

Given that CARPs have several potential neuroprotective mechanisms of action is highly significant, as it is widely considered that to obtain neuroprotective efficacy at the clinical level will require a combination of treatments or a treatment targeting two or more neurodamaging and/or neuroprotective pathways.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.