Evaluation of tractography in relation to XDP clinical variables and putaminal volume There was a trend toward significance in the relationship between left insula-putamen connectivity and the BFM mouth dystonia score in XDP patients (R = 0.538; p = 0.0316; Fig. 3 D).
Posthoc evaluation of tractography for individual seed-endpoint pairs Further evaluation of individual regions/hemispheres between striosome-weighted cortex and putamen led to the following findings: all three cortical regions, including both hemispheres, showed higher mean connectivity in XDP patients in the 17 versus 17 cohort, except for left anterior/subcallosal cingulate, which showed a trend toward reduced connectivity with the putamen in XDP ( Table 5 ; Fig. 3 ).