BRD4 Promotes DNA Repair and Mediates the Formation of TMPRSS2-ERG Gene Rearrangements in Prostate Cancer.

Cell Rep · 2018 · PMC5843368 · PMID 29346775

Europe PMC DOI

hedged sentences

0.0800

closest p · 1.6× alpha

0.1100

boldest claim

The sentences

near significancep = 0.08so close (0.05 < p ≤ 0.1)

The results of gene set enrichment analysis tests indicated that treatment with I-BET151 regulated the NHEJ pathway with near significance (p = 0.08).

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did not reach statistical significancep = 0.11not close (p > 0.1)

Although those patients in the high BRD4 group had a worse outcome compared to those in the low BRD4 group, this did not reach statistical significance (median 8.0 [IQR 5.1–13.5] versus 13.3 [IQR 7.9–13.8] years, HR 2.1 [0.8–5.5], p = 0.11; Figure 7D ).

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