An Increased Frequency in HLA Class I Alleles and Haplotypes Suggests Genetic Susceptibility to Influenza A (H1N1) 2009 Pandemic: A Case-Control Study.

J Immunol Res · 2018 · PMC5845504 · PMID 29682588

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did not reach statistical significanceno p-value reported

A lower frequency of A∗11:01:01 (0.4% versus 2.8%, p = 1.63 E − 02) was also observed in INF-C but did not reach statistical significance after Bonferroni correction ( Table 2 ).

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failed to reach significanceno p-value reported

B∗39:06:02 ( p = 2.12 E − 02), B∗44:03:01 ( p = 3.55 E − 03), and B∗73:01 ( p = 8.99 E − 03) were also increased in the INF-P group but failed to reach significance after Bonferroni correction (OR = 2.53–9.98).

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highly significantno p-value reported

Two highly significant haplotypes—A∗68:01:02-C∗07:02:01 (pC = 2.53 E − 04, OR = 23.99, CI = 3.14–183.51) and B∗35:01:01-C∗07:02:01 (pC = 6.64 E − 03, OR = 16.88, CI = 2.14–132.60)—were observed in the INF-P, suggesting that these haplotypes are important genetic susceptibility factors predisposing them to symptomatic influenza A H1N1/09 viral infection.

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