There were fewer treatment discontinuations in the ROF 500 μg EOD/500 μg OD group compared with the ROF 500 μg OD group, but this difference did not reach statistical significance (20.1% versus 24.6%; RR 0.81 [95% CI 0.62–1.05], OR 0.76 [95% CI 0.55–1.07], p =0.114; Figure 2 ).
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Use of a 4-week up-titration regimen of roflumilast in patients with severe COPD.
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0.1140
0.1140