Evaluation of three polygenic risk score models for the prediction of breast cancer risk in Singapore Chinese.

Oncotarget · 2018 · PMC5849174 · PMID 29560110

Europe PMC DOI

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failed to reach statistical significanceno p-value reported

[ 32 ], were not found to be statistically significant with BC risk in our study, it is possible that some of these SNPs failed to reach statistical significance as our study could have had insufficient power to detect the associations and additional studies of Asian ancestry are thus warranted to confirm if these SNPs are significantly associated with BC risk.

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an overall trendno p-value reported

In addition, we performed logistic regression analysis based on PRS quartiles which showed an overall trend across models and groups, and the highest quartile predicted to have the highest OR thus implying a direct correlation between PRS and OR.

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of borderline significanceno p-value reported

Though these associations were only found to be of borderline significance, we should not discount the importance of FGFR2 as a BC susceptibility locus in our population.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.