Although there was a trend toward decreased heart weight with ADAMTS13 treatment compared with vehicle treatment, this did not reach statistical significance ( P =0.10 by Mann‐Whitney U test).
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Recombinant Human ADAMTS13 Treatment Improves Myocardial Remodeling and Functionality After Pressure Overload Injury in Mice.
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Reduction was highly significant at the highest dose of 3460 U/kg, whereas the lowest dose of 40 U/kg had no effect (Figure 2 B).